Sesamin modulates tyrosine hydroxylase, superoxide dismutase, catalase, inducible NO synthase and interleukin-6 expression in dopaminergic cells under MPP+-induced oxidative stress
Identifieur interne : 002144 ( Main/Exploration ); précédent : 002143; suivant : 002145Sesamin modulates tyrosine hydroxylase, superoxide dismutase, catalase, inducible NO synthase and interleukin-6 expression in dopaminergic cells under MPP+-induced oxidative stress
Auteurs : Vicky Lahaie-Collins ; Julie Bournival ; Marilyn Plouffe ; Julie Carange ; Maria-Grazia MartinoliSource :
- Oxidative Medicine and Cellular Longevity [ 1942-0900 ] ; 2008.
English descriptors
- KwdEn :
- 1-Methyl-4-phenylpyridinium (pharmacology), Animals, Antioxidants (pharmacology), Catalase (biosynthesis), Catalase (metabolism), Dioxoles (pharmacology), Dopamine (metabolism), Dopamine Plasma Membrane Transport Proteins (metabolism), Interleukin-6 (biosynthesis), Interleukin-6 (metabolism), Lignans (pharmacology), Neurons (drug effects), Neurons (enzymology), Neurons (metabolism), Nitric Oxide Synthase Type II (biosynthesis), Nitric Oxide Synthase Type II (metabolism), Oxidative Stress (drug effects), Oxidative Stress (physiology), PC12 Cells, Rats, Reactive Oxygen Species (metabolism), Superoxide Dismutase (biosynthesis), Superoxide Dismutase (metabolism), Tyrosine 3-Monooxygenase (biosynthesis), Tyrosine 3-Monooxygenase (metabolism).
- MESH :
- chemical , biosynthesis : Catalase, Interleukin-6, Nitric Oxide Synthase Type II, Superoxide Dismutase, Tyrosine 3-Monooxygenase.
- chemical , metabolism : Catalase, Dopamine, Dopamine Plasma Membrane Transport Proteins, Interleukin-6, Nitric Oxide Synthase Type II, Reactive Oxygen Species, Superoxide Dismutase, Tyrosine 3-Monooxygenase.
- chemical , pharmacology : 1-Methyl-4-phenylpyridinium, Antioxidants, Dioxoles, Lignans.
- drug effects : Neurons, Oxidative Stress.
- enzymology : Neurons.
- metabolism : Neurons.
- physiology : Oxidative Stress.
- Animals, PC12 Cells, Rats.
Abstract
Oxidative stress is regarded as a mediator of nerve cell death in several neurodegenerative disorders, such as Parkinson's disease. Sesamin, a lignan mainly found in sesame oil, is currently under study for its anti-oxidative and possible neuroprotective properties. We used 1-methyl-4-phenyl-pyridine (MPP+) ion, the active metabolite of the potent parkinsonism-causing toxin 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine, to produce oxidative stress and neurodegeneration in neuronal PC12 cells, which express dopamine, as well as neurofilaments. Our results show that picomolar doses of sesamin protected neuronal PC12 cells from MPP+-induced cellular death, as revealed by colorimetric measurements and production of reactive oxygen species. We also demonstrated that sesamin acted by rescuing tyrosine hydroxylase levels from MPP+-induced depletion. Sesamin, however, did not modulate dopamine transporter levels, and estrogen receptor-alpha and -beta protein expression. By examining several parameters of cell distress, we found that sesamin also elicited a strong increase in superoxide dismutase activity as well as protein expression and decreased catalase activity and the MPP+ stimulated inducible nitric oxide synthase protein expression, in neuronal PC12 cells. Finally, sesamin possessed significant anti-inflammatory properties, as disclosed by its potential to reduce MPP+-induced interleukin-6 mRNA levels in microglia. From these studies, we determined the importance of the lignan sesamin as a neuroprotective molecule and its possible role in complementary and/or preventive therapies of neurodegenerative diseases.
Url:
PubMed: 19794909
PubMed Central: 2715194
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000A62
- to stream Pmc, to step Curation: 000A62
- to stream Pmc, to step Checkpoint: 000B51
- to stream PubMed, to step Corpus: 000F45
- to stream PubMed, to step Curation: 000F45
- to stream PubMed, to step Checkpoint: 000F45
- to stream Ncbi, to step Merge: 000B57
- to stream Ncbi, to step Curation: 000B57
- to stream Ncbi, to step Checkpoint: 000B57
- to stream Main, to step Merge: 002329
- to stream Main, to step Curation: 002144
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Sesamin modulates tyrosine hydroxylase, superoxide dismutase, catalase, inducible NO synthase and interleukin-6 expression in dopaminergic cells under MPP<sup>+</sup>-induced oxidative stress</title><author><name sortKey="Lahaie Collins, Vicky" sort="Lahaie Collins, Vicky" uniqKey="Lahaie Collins V" first="Vicky" last="Lahaie-Collins">Vicky Lahaie-Collins</name><affiliation><nlm:aff id="A1">Department of Biochemistry and the Neuroscience Research Group; Université du Québec; Trois-Rivières, Québec Canada</nlm:aff><wicri:noCountry code="subfield">Québec Canada</wicri:noCountry></affiliation></author><author><name sortKey="Bournival, Julie" sort="Bournival, Julie" uniqKey="Bournival J" first="Julie" last="Bournival">Julie Bournival</name><affiliation><nlm:aff id="A1">Department of Biochemistry and the Neuroscience Research Group; Université du Québec; Trois-Rivières, Québec Canada</nlm:aff><wicri:noCountry code="subfield">Québec Canada</wicri:noCountry></affiliation></author><author><name sortKey="Plouffe, Marilyn" sort="Plouffe, Marilyn" uniqKey="Plouffe M" first="Marilyn" last="Plouffe">Marilyn Plouffe</name><affiliation><nlm:aff id="A1">Department of Biochemistry and the Neuroscience Research Group; Université du Québec; Trois-Rivières, Québec Canada</nlm:aff><wicri:noCountry code="subfield">Québec Canada</wicri:noCountry></affiliation></author><author><name sortKey="Carange, Julie" sort="Carange, Julie" uniqKey="Carange J" first="Julie" last="Carange">Julie Carange</name><affiliation><nlm:aff id="A1">Department of Biochemistry and the Neuroscience Research Group; Université du Québec; Trois-Rivières, Québec Canada</nlm:aff><wicri:noCountry code="subfield">Québec Canada</wicri:noCountry></affiliation></author><author><name sortKey="Martinoli, Maria Grazia" sort="Martinoli, Maria Grazia" uniqKey="Martinoli M" first="Maria-Grazia" last="Martinoli">Maria-Grazia Martinoli</name><affiliation><nlm:aff id="A1">Department of Biochemistry and the Neuroscience Research Group; Université du Québec; Trois-Rivières, Québec Canada</nlm:aff><wicri:noCountry code="subfield">Québec Canada</wicri:noCountry></affiliation><affiliation><nlm:aff id="A2">Neuroscience Research Unit; Université Laval; Québec Canada</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19794909</idno><idno type="pmc">2715194</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715194</idno><idno type="RBID">PMC:2715194</idno><date when="2008">2008</date><idno type="wicri:Area/Pmc/Corpus">000A62</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A62</idno><idno type="wicri:Area/Pmc/Curation">000A62</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A62</idno><idno type="wicri:Area/Pmc/Checkpoint">000B51</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000B51</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000F45</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000F45</idno><idno type="wicri:Area/PubMed/Curation">000F45</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000F45</idno><idno type="wicri:Area/PubMed/Checkpoint">000F45</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000F45</idno><idno type="wicri:Area/Ncbi/Merge">000B57</idno><idno type="wicri:Area/Ncbi/Curation">000B57</idno><idno type="wicri:Area/Ncbi/Checkpoint">000B57</idno><idno type="wicri:doubleKey">1942-0900:2008:Lahaie Collins V:sesamin:modulates:tyrosine</idno><idno type="wicri:Area/Main/Merge">002329</idno><idno type="wicri:Area/Main/Curation">002144</idno><idno type="wicri:Area/Main/Exploration">002144</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Sesamin modulates tyrosine hydroxylase, superoxide dismutase, catalase, inducible NO synthase and interleukin-6 expression in dopaminergic cells under MPP<sup>+</sup>-induced oxidative stress</title><author><name sortKey="Lahaie Collins, Vicky" sort="Lahaie Collins, Vicky" uniqKey="Lahaie Collins V" first="Vicky" last="Lahaie-Collins">Vicky Lahaie-Collins</name><affiliation><nlm:aff id="A1">Department of Biochemistry and the Neuroscience Research Group; Université du Québec; Trois-Rivières, Québec Canada</nlm:aff><wicri:noCountry code="subfield">Québec Canada</wicri:noCountry></affiliation></author><author><name sortKey="Bournival, Julie" sort="Bournival, Julie" uniqKey="Bournival J" first="Julie" last="Bournival">Julie Bournival</name><affiliation><nlm:aff id="A1">Department of Biochemistry and the Neuroscience Research Group; Université du Québec; Trois-Rivières, Québec Canada</nlm:aff><wicri:noCountry code="subfield">Québec Canada</wicri:noCountry></affiliation></author><author><name sortKey="Plouffe, Marilyn" sort="Plouffe, Marilyn" uniqKey="Plouffe M" first="Marilyn" last="Plouffe">Marilyn Plouffe</name><affiliation><nlm:aff id="A1">Department of Biochemistry and the Neuroscience Research Group; Université du Québec; Trois-Rivières, Québec Canada</nlm:aff><wicri:noCountry code="subfield">Québec Canada</wicri:noCountry></affiliation></author><author><name sortKey="Carange, Julie" sort="Carange, Julie" uniqKey="Carange J" first="Julie" last="Carange">Julie Carange</name><affiliation><nlm:aff id="A1">Department of Biochemistry and the Neuroscience Research Group; Université du Québec; Trois-Rivières, Québec Canada</nlm:aff><wicri:noCountry code="subfield">Québec Canada</wicri:noCountry></affiliation></author><author><name sortKey="Martinoli, Maria Grazia" sort="Martinoli, Maria Grazia" uniqKey="Martinoli M" first="Maria-Grazia" last="Martinoli">Maria-Grazia Martinoli</name><affiliation><nlm:aff id="A1">Department of Biochemistry and the Neuroscience Research Group; Université du Québec; Trois-Rivières, Québec Canada</nlm:aff><wicri:noCountry code="subfield">Québec Canada</wicri:noCountry></affiliation><affiliation><nlm:aff id="A2">Neuroscience Research Unit; Université Laval; Québec Canada</nlm:aff></affiliation></author></analytic><series><title level="j">Oxidative Medicine and Cellular Longevity</title><idno type="ISSN">1942-0900</idno><idno type="eISSN">1942-0994</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>1-Methyl-4-phenylpyridinium (pharmacology)</term><term>Animals</term><term>Antioxidants (pharmacology)</term><term>Catalase (biosynthesis)</term><term>Catalase (metabolism)</term><term>Dioxoles (pharmacology)</term><term>Dopamine (metabolism)</term><term>Dopamine Plasma Membrane Transport Proteins (metabolism)</term><term>Interleukin-6 (biosynthesis)</term><term>Interleukin-6 (metabolism)</term><term>Lignans (pharmacology)</term><term>Neurons (drug effects)</term><term>Neurons (enzymology)</term><term>Neurons (metabolism)</term><term>Nitric Oxide Synthase Type II (biosynthesis)</term><term>Nitric Oxide Synthase Type II (metabolism)</term><term>Oxidative Stress (drug effects)</term><term>Oxidative Stress (physiology)</term><term>PC12 Cells</term><term>Rats</term><term>Reactive Oxygen Species (metabolism)</term><term>Superoxide Dismutase (biosynthesis)</term><term>Superoxide Dismutase (metabolism)</term><term>Tyrosine 3-Monooxygenase (biosynthesis)</term><term>Tyrosine 3-Monooxygenase (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Catalase</term><term>Interleukin-6</term><term>Nitric Oxide Synthase Type II</term><term>Superoxide Dismutase</term><term>Tyrosine 3-Monooxygenase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Catalase</term><term>Dopamine</term><term>Dopamine Plasma Membrane Transport Proteins</term><term>Interleukin-6</term><term>Nitric Oxide Synthase Type II</term><term>Reactive Oxygen Species</term><term>Superoxide Dismutase</term><term>Tyrosine 3-Monooxygenase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>1-Methyl-4-phenylpyridinium</term><term>Antioxidants</term><term>Dioxoles</term><term>Lignans</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Neurons</term><term>Oxidative Stress</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Neurons</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Neurons</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Oxidative Stress</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>PC12 Cells</term><term>Rats</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Oxidative stress is regarded as a mediator of nerve cell death in several neurodegenerative disorders, such as Parkinson's disease. Sesamin, a lignan mainly found in sesame oil, is currently under study for its anti-oxidative and possible neuroprotective properties. We used 1-methyl-4-phenyl-pyridine (MPP<sup>+</sup>) ion, the active metabolite of the potent parkinsonism-causing toxin 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine, to produce oxidative stress and neurodegeneration in neuronal PC12 cells, which express dopamine, as well as neurofilaments. Our results show that picomolar doses of sesamin protected neuronal PC12 cells from MPP<sup>+</sup>-induced cellular death, as revealed by colorimetric measurements and production of reactive oxygen species. We also demonstrated that sesamin acted by rescuing tyrosine hydroxylase levels from MPP<sup>+</sup>-induced depletion. Sesamin, however, did not modulate dopamine transporter levels, and estrogen receptor-alpha and -beta protein expression. By examining several parameters of cell distress, we found that sesamin also elicited a strong increase in superoxide dismutase activity as well as protein expression and decreased catalase activity and the MPP<sup>+</sup> stimulated inducible nitric oxide synthase protein expression, in neuronal PC12 cells. Finally, sesamin possessed significant anti-inflammatory properties, as disclosed by its potential to reduce MPP<sup>+</sup>-induced interleukin-6 mRNA levels in microglia. From these studies, we determined the importance of the lignan sesamin as a neuroprotective molecule and its possible role in complementary and/or preventive therapies of neurodegenerative diseases.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Dawson, Vl" uniqKey="Dawson V">VL Dawson</name></author><author><name sortKey="Dawson, Tm" uniqKey="Dawson T">TM Dawson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jenner, P" uniqKey="Jenner P">P Jenner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marchetti, B" uniqKey="Marchetti B">B Marchetti</name></author><author><name sortKey="Abbracchio, Mp" uniqKey="Abbracchio M">MP Abbracchio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Andersen, Jk" uniqKey="Andersen J">JK Andersen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alam, Zi" uniqKey="Alam Z">ZI Alam</name></author><author><name sortKey="Jenner, A" uniqKey="Jenner A">A Jenner</name></author><author><name sortKey="Daniel, Se" uniqKey="Daniel S">SE Daniel</name></author><author><name sortKey="Lees, Aj" uniqKey="Lees A">AJ Lees</name></author><author><name sortKey="Cairns, N" uniqKey="Cairns N">N Cairns</name></author><author><name sortKey="Marsden, Cd" uniqKey="Marsden C">CD Marsden</name></author><author><name sortKey="Jenner, P" uniqKey="Jenner P">P Jenner</name></author><author><name sortKey="Halliwell, B" uniqKey="Halliwell B">B Halliwell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maier, Cm" uniqKey="Maier C">CM Maier</name></author><author><name sortKey="Chan, Ph" uniqKey="Chan P">PH Chan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Langston, Jw" uniqKey="Langston J">JW Langston</name></author><author><name sortKey="Irwin, I" uniqKey="Irwin I">I Irwin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Heikkila, Re" uniqKey="Heikkila R">RE Heikkila</name></author><author><name sortKey="Sieber, Ba" uniqKey="Sieber B">BA Sieber</name></author><author><name sortKey="Manzino, L" uniqKey="Manzino L">L Manzino</name></author><author><name sortKey="Sonsalla, Pk" uniqKey="Sonsalla P">PK Sonsalla</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kopin, Ij" uniqKey="Kopin I">IJ Kopin</name></author><author><name sortKey="Markey, Sp" uniqKey="Markey S">SP Markey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schober, A" uniqKey="Schober A">A Schober</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Segura, Aguilar J" uniqKey="Segura A">Aguilar J Segura</name></author><author><name sortKey="Kostrzewa, Rm" uniqKey="Kostrzewa R">RM Kostrzewa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koppenol, Wh" uniqKey="Koppenol W">WH Koppenol</name></author><author><name sortKey="Moreno, Jj" uniqKey="Moreno J">JJ Moreno</name></author><author><name sortKey="Pryor, Wa" uniqKey="Pryor W">WA Pryor</name></author><author><name sortKey="Ischiropoulos, H" uniqKey="Ischiropoulos H">H Ischiropoulos</name></author><author><name sortKey="Beckman, Js" uniqKey="Beckman J">JS Beckman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Obata, T" uniqKey="Obata T">T Obata</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hemalatha, S" uniqKey="Hemalatha S">S Hemalatha</name></author><author><name sortKey="Raghunath, M" uniqKey="Raghunath M">M Raghunath</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Suja, Kp" uniqKey="Suja K">KP Suja</name></author><author><name sortKey="Jayalekshmy, A" uniqKey="Jayalekshmy A">A Jayalekshmy</name></author><author><name sortKey="Arumughan, C" uniqKey="Arumughan C">C Arumughan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ghafoorunissa" uniqKey="Ghafoorunissa">Ghafoorunissa</name></author><author><name sortKey="Hemalatha, S" uniqKey="Hemalatha S">S Hemalatha</name></author><author><name sortKey="Rao, Mv" uniqKey="Rao M">MV Rao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shahidi, F" uniqKey="Shahidi F">F Shahidi</name></author><author><name sortKey="Wanasundara, Pk" uniqKey="Wanasundara P">PK Wanasundara</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hirata, F" uniqKey="Hirata F">F Hirata</name></author><author><name sortKey="Fujita, K" uniqKey="Fujita K">K Fujita</name></author><author><name sortKey="Ishikura, Y" uniqKey="Ishikura Y">Y Ishikura</name></author><author><name sortKey="Hosoda, K" uniqKey="Hosoda K">K Hosoda</name></author><author><name sortKey="Ishikawa, T" uniqKey="Ishikawa T">T Ishikawa</name></author><author><name sortKey="Nakamura, H" uniqKey="Nakamura H">H Nakamura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Cc" uniqKey="Lee C">CC Lee</name></author><author><name sortKey="Chen, Pr" uniqKey="Chen P">PR Chen</name></author><author><name sortKey="Lin, S" uniqKey="Lin S">S Lin</name></author><author><name sortKey="Tsai, Sc" uniqKey="Tsai S">SC Tsai</name></author><author><name sortKey="Wang, Bw" uniqKey="Wang B">BW Wang</name></author><author><name sortKey="Chen, Ww" uniqKey="Chen W">WW Chen</name></author><author><name sortKey="Tsai, Ce" uniqKey="Tsai C">CE Tsai</name></author><author><name sortKey="Shyu, Kg" uniqKey="Shyu K">KG Shyu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Noguchi, T" uniqKey="Noguchi T">T Noguchi</name></author><author><name sortKey="Ikeda, K" uniqKey="Ikeda K">K Ikeda</name></author><author><name sortKey="Sasaki, Y" uniqKey="Sasaki Y">Y Sasaki</name></author><author><name sortKey="Yamamoto, J" uniqKey="Yamamoto J">J Yamamoto</name></author><author><name sortKey="Seki, J" uniqKey="Seki J">J Seki</name></author><author><name sortKey="Yamagata, K" uniqKey="Yamagata K">K Yamagata</name></author><author><name sortKey="Nara, Y" uniqKey="Nara Y">Y Nara</name></author><author><name sortKey="Hara, H" uniqKey="Hara H">H Hara</name></author><author><name sortKey="Kakuta, H" uniqKey="Kakuta H">H Kakuta</name></author><author><name sortKey="Yamori, Y" uniqKey="Yamori Y">Y Yamori</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nakano, D" uniqKey="Nakano D">D Nakano</name></author><author><name sortKey="Kwak, Cj" uniqKey="Kwak C">CJ Kwak</name></author><author><name sortKey="Fujii, K" uniqKey="Fujii K">K Fujii</name></author><author><name sortKey="Ikemura, K" uniqKey="Ikemura K">K Ikemura</name></author><author><name sortKey="Satake, A" uniqKey="Satake A">A Satake</name></author><author><name sortKey="Ohkita, M" uniqKey="Ohkita M">M Ohkita</name></author><author><name sortKey="Takaoka, M" uniqKey="Takaoka M">M Takaoka</name></author><author><name sortKey="Ono, Y" uniqKey="Ono Y">Y Ono</name></author><author><name sortKey="Nakai, M" uniqKey="Nakai M">M Nakai</name></author><author><name sortKey="Tomimori, N" uniqKey="Tomimori N">N Tomimori</name></author><author><name sortKey="Kiso, Y" uniqKey="Kiso Y">Y Kiso</name></author><author><name sortKey="Matsumura, Y" uniqKey="Matsumura Y">Y Matsumura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kiso, Y" uniqKey="Kiso Y">Y Kiso</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fujikawa, T" uniqKey="Fujikawa T">T Fujikawa</name></author><author><name sortKey="Kanada, N" uniqKey="Kanada N">N Kanada</name></author><author><name sortKey="Shimada, A" uniqKey="Shimada A">A Shimada</name></author><author><name sortKey="Ogata, M" uniqKey="Ogata M">M Ogata</name></author><author><name sortKey="Suzuki, I" uniqKey="Suzuki I">I Suzuki</name></author><author><name sortKey="Hayashi, I" uniqKey="Hayashi I">I Hayashi</name></author><author><name sortKey="Nakashima, K" uniqKey="Nakashima K">K Nakashima</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jeng, Kc" uniqKey="Jeng K">KC Jeng</name></author><author><name sortKey="Hou, Rc" uniqKey="Hou R">RC Hou</name></author><author><name sortKey="Wang, Jc" uniqKey="Wang J">JC Wang</name></author><author><name sortKey="Ping, Li" uniqKey="Ping L">LI Ping</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gelinas, S" uniqKey="Gelinas S">S Gelinas</name></author><author><name sortKey="Martinoli, Mg" uniqKey="Martinoli M">MG Martinoli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gagne, B" uniqKey="Gagne B">B Gagne</name></author><author><name sortKey="Gelinas, S" uniqKey="Gelinas S">S Gelinas</name></author><author><name sortKey="Bureau, G" uniqKey="Bureau G">G Bureau</name></author><author><name sortKey="Lagace, B" uniqKey="Lagace B">B Lagace</name></author><author><name sortKey="Ramassamy, C" uniqKey="Ramassamy C">C Ramassamy</name></author><author><name sortKey="Chiasson, K" uniqKey="Chiasson K">K Chiasson</name></author><author><name sortKey="Valastro, B" uniqKey="Valastro B">B Valastro</name></author><author><name sortKey="Martinoli, Mg" uniqKey="Martinoli M">MG Martinoli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miwa, H" uniqKey="Miwa H">H Miwa</name></author><author><name sortKey="Kubo, T" uniqKey="Kubo T">T Kubo</name></author><author><name sortKey="Morita, S" uniqKey="Morita S">S Morita</name></author><author><name sortKey="Nakanishi, I" uniqKey="Nakanishi I">I Nakanishi</name></author><author><name sortKey="Kondo, T" uniqKey="Kondo T">T Kondo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Henze, C" uniqKey="Henze C">C Henze</name></author><author><name sortKey="Hartmann, A" uniqKey="Hartmann A">A Hartmann</name></author><author><name sortKey="Lescot, T" uniqKey="Lescot T">T Lescot</name></author><author><name sortKey="Hirsch, Ec" uniqKey="Hirsch E">EC Hirsch</name></author><author><name sortKey="Michel, Pp" uniqKey="Michel P">PP Michel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martin, A" uniqKey="Martin A">A Martin</name></author><author><name sortKey="Clynes, M" uniqKey="Clynes M">M Clynes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Decker, T" uniqKey="Decker T">T Decker</name></author><author><name sortKey="Lohmann Matthes, Ml" uniqKey="Lohmann Matthes M">ML Lohmann-Matthes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gelinas, S" uniqKey="Gelinas S">S Gelinas</name></author><author><name sortKey="Bureau, G" uniqKey="Bureau G">G Bureau</name></author><author><name sortKey="Valastro, B" uniqKey="Valastro B">B Valastro</name></author><author><name sortKey="Massicotte, G" uniqKey="Massicotte G">G Massicotte</name></author><author><name sortKey="Cicchetti, F" uniqKey="Cicchetti F">F Cicchetti</name></author><author><name sortKey="Chiasson, K" uniqKey="Chiasson K">K Chiasson</name></author><author><name sortKey="Gagne, B" uniqKey="Gagne B">B Gagne</name></author><author><name sortKey="Blanchet, J" uniqKey="Blanchet J">J Blanchet</name></author><author><name sortKey="Martinoli, Mg" uniqKey="Martinoli M">MG Martinoli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frantseva, Mv" uniqKey="Frantseva M">MV Frantseva</name></author><author><name sortKey="Carlen, Pl" uniqKey="Carlen P">PL Carlen</name></author><author><name sortKey="Perez Velazquez, Jl" uniqKey="Perez Velazquez J">JL Perez Velazquez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vandesompele, J" uniqKey="Vandesompele J">J Vandesompele</name></author><author><name sortKey="De Preter, K" uniqKey="De Preter K">K De Preter</name></author><author><name sortKey="Pattyn, F" uniqKey="Pattyn F">F Pattyn</name></author><author><name sortKey="Poppe, B" uniqKey="Poppe B">B Poppe</name></author><author><name sortKey="Van Roy, N" uniqKey="Van Roy N">N Van Roy</name></author><author><name sortKey="De Paepe, A" uniqKey="De Paepe A">A De Paepe</name></author><author><name sortKey="Speleman, F" uniqKey="Speleman F">F Speleman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Henderson, Lm" uniqKey="Henderson L">LM Henderson</name></author><author><name sortKey="Chappell, Jb" uniqKey="Chappell J">JB Chappell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kooy, Nw" uniqKey="Kooy N">NW Kooy</name></author><author><name sortKey="Royall, Ja" uniqKey="Royall J">JA Royall</name></author><author><name sortKey="Ischiropoulos, H" uniqKey="Ischiropoulos H">H Ischiropoulos</name></author><author><name sortKey="Beckman, Js" uniqKey="Beckman J">JS Beckman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thomas, B" uniqKey="Thomas B">B Thomas</name></author><author><name sortKey="Saravanan, Ks" uniqKey="Saravanan K">KS Saravanan</name></author><author><name sortKey="Mohanakumar, Kp" uniqKey="Mohanakumar K">KP Mohanakumar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cheng, Yh" uniqKey="Cheng Y">YH Cheng</name></author><author><name sortKey="Ding, St" uniqKey="Ding S">ST Ding</name></author><author><name sortKey="Chang, Mh" uniqKey="Chang M">MH Chang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Galati, G" uniqKey="Galati G">G Galati</name></author><author><name sortKey="Sabzevari, O" uniqKey="Sabzevari O">O Sabzevari</name></author><author><name sortKey="Wilson, Jx" uniqKey="Wilson J">JX Wilson</name></author><author><name sortKey="O Brien, Pj" uniqKey="O Brien P">PJ O'Brien</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anekonda, Ts" uniqKey="Anekonda T">TS Anekonda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hartman, Re" uniqKey="Hartman R">RE Hartman</name></author><author><name sortKey="Shah, A" uniqKey="Shah A">A Shah</name></author><author><name sortKey="Fagan, Am" uniqKey="Fagan A">AM Fagan</name></author><author><name sortKey="Schwetye, Ke" uniqKey="Schwetye K">KE Schwetye</name></author><author><name sortKey="Parsadanian, M" uniqKey="Parsadanian M">M Parsadanian</name></author><author><name sortKey="Schulman, Rn" uniqKey="Schulman R">RN Schulman</name></author><author><name sortKey="Finn, Mb" uniqKey="Finn M">MB Finn</name></author><author><name sortKey="Holtzman, Dm" uniqKey="Holtzman D">DM Holtzman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baur, Ja" uniqKey="Baur J">JA Baur</name></author><author><name sortKey="Pearson, Kj" uniqKey="Pearson K">KJ Pearson</name></author><author><name sortKey="Price, Nl" uniqKey="Price N">NL Price</name></author><author><name sortKey="Jamieson, Ha" uniqKey="Jamieson H">HA Jamieson</name></author><author><name sortKey="Lerin, C" uniqKey="Lerin C">C Lerin</name></author><author><name sortKey="Kalra, A" uniqKey="Kalra A">A Kalra</name></author><author><name sortKey="Prabhu, Vv" uniqKey="Prabhu V">VV Prabhu</name></author><author><name sortKey="Allard, Js" uniqKey="Allard J">JS Allard</name></author><author><name sortKey="Lopez Lluch, G" uniqKey="Lopez Lluch G">G Lopez-Lluch</name></author><author><name sortKey="Lewis, K" uniqKey="Lewis K">K Lewis</name></author><author><name sortKey="Pistell, Pj" uniqKey="Pistell P">PJ Pistell</name></author><author><name sortKey="Poosala, S" uniqKey="Poosala S">S Poosala</name></author><author><name sortKey="Becker, Kg" uniqKey="Becker K">KG Becker</name></author><author><name sortKey="Boss, O" uniqKey="Boss O">O Boss</name></author><author><name sortKey="Gwinn, D" uniqKey="Gwinn D">D Gwinn</name></author><author><name sortKey="Wang, M" uniqKey="Wang M">M Wang</name></author><author><name sortKey="Ramaswamy, S" uniqKey="Ramaswamy S">S Ramaswamy</name></author><author><name sortKey="Fishbein, Kw" uniqKey="Fishbein K">KW Fishbein</name></author><author><name sortKey="Spencer, Rg" uniqKey="Spencer R">RG Spencer</name></author><author><name sortKey="Lakatta, Eg" uniqKey="Lakatta E">EG Lakatta</name></author><author><name sortKey="Le Couteur, D" uniqKey="Le Couteur D">D Le Couteur</name></author><author><name sortKey="Shaw, Rj" uniqKey="Shaw R">RJ Shaw</name></author><author><name sortKey="Navas, P" uniqKey="Navas P">P Navas</name></author><author><name sortKey="Puigserver, P" uniqKey="Puigserver P">P Puigserver</name></author><author><name sortKey="Ingram, Dk" uniqKey="Ingram D">DK Ingram</name></author><author><name sortKey="De Cabo, R" uniqKey="De Cabo R">R de Cabo</name></author><author><name sortKey="Sinclair, Da" uniqKey="Sinclair D">DA Sinclair</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chiasson, K" uniqKey="Chiasson K">K Chiasson</name></author><author><name sortKey="Daoust, B" uniqKey="Daoust B">B Daoust</name></author><author><name sortKey="Levesque, D" uniqKey="Levesque D">D Levesque</name></author><author><name sortKey="Martinoli, Mg" uniqKey="Martinoli M">MG Martinoli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kadota, T" uniqKey="Kadota T">T Kadota</name></author><author><name sortKey="Yamaai, T" uniqKey="Yamaai T">T Yamaai</name></author><author><name sortKey="Saito, Y" uniqKey="Saito Y">Y Saito</name></author><author><name sortKey="Akita, Y" uniqKey="Akita Y">Y Akita</name></author><author><name sortKey="Kawashima, S" uniqKey="Kawashima S">S Kawashima</name></author><author><name sortKey="Moroi, K" uniqKey="Moroi K">K Moroi</name></author><author><name sortKey="Inagaki, N" uniqKey="Inagaki N">N Inagaki</name></author><author><name sortKey="Kadota, K" uniqKey="Kadota K">K Kadota</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nilsen, J" uniqKey="Nilsen J">J Nilsen</name></author><author><name sortKey="Mor, G" uniqKey="Mor G">G Mor</name></author><author><name sortKey="Naftolin, F" uniqKey="Naftolin F">F Naftolin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chiasson, K" uniqKey="Chiasson K">K Chiasson</name></author><author><name sortKey="Lahaie Collins, V" uniqKey="Lahaie Collins V">V Lahaie-Collins</name></author><author><name sortKey="Bournival, J" uniqKey="Bournival J">J Bournival</name></author><author><name sortKey="Delapierre, B" uniqKey="Delapierre B">B Delapierre</name></author><author><name sortKey="Gelinas, S" uniqKey="Gelinas S">S Gelinas</name></author><author><name sortKey="Martinoli, Mg" uniqKey="Martinoli M">MG Martinoli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, V" uniqKey="Lee V">V Lee</name></author><author><name sortKey="Trojanowski, Jq" uniqKey="Trojanowski J">JQ Trojanowski</name></author><author><name sortKey="Schlaepfer, Ww" uniqKey="Schlaepfer W">WW Schlaepfer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vitaglione, P" uniqKey="Vitaglione P">P Vitaglione</name></author><author><name sortKey="Sforza, S" uniqKey="Sforza S">S Sforza</name></author><author><name sortKey="Galaverna, G" uniqKey="Galaverna G">G Galaverna</name></author><author><name sortKey="Ghidini, C" uniqKey="Ghidini C">C Ghidini</name></author><author><name sortKey="Caporaso, N" uniqKey="Caporaso N">N Caporaso</name></author><author><name sortKey="Vescovi, Pp" uniqKey="Vescovi P">PP Vescovi</name></author><author><name sortKey="Fogliano, V" uniqKey="Fogliano V">V Fogliano</name></author><author><name sortKey="Marchelli, R" uniqKey="Marchelli R">R Marchelli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ross, Ja" uniqKey="Ross J">JA Ross</name></author><author><name sortKey="Kasum, Cm" uniqKey="Kasum C">CM Kasum</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Umeda Sawada, R" uniqKey="Umeda Sawada R">R Umeda-Sawada</name></author><author><name sortKey="Ogawa, M" uniqKey="Ogawa M">M Ogawa</name></author><author><name sortKey="Igarashi, O" uniqKey="Igarashi O">O Igarashi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mccarty, Mf" uniqKey="Mccarty M">MF McCarty</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drechsel, Da" uniqKey="Drechsel D">DA Drechsel</name></author><author><name sortKey="Patel, M" uniqKey="Patel M">M Patel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nunomura, A" uniqKey="Nunomura A">A Nunomura</name></author><author><name sortKey="Moreira, Pi" uniqKey="Moreira P">PI Moreira</name></author><author><name sortKey="Lee, Hg" uniqKey="Lee H">HG Lee</name></author><author><name sortKey="Zhu, X" uniqKey="Zhu X">X Zhu</name></author><author><name sortKey="Castellani, Rj" uniqKey="Castellani R">RJ Castellani</name></author><author><name sortKey="Smith, Ma" uniqKey="Smith M">MA Smith</name></author><author><name sortKey="Perry, G" uniqKey="Perry G">G Perry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Currie, Lj" uniqKey="Currie L">LJ Currie</name></author><author><name sortKey="Harrison, Mb" uniqKey="Harrison M">MB Harrison</name></author><author><name sortKey="Trugman, Jm" uniqKey="Trugman J">JM Trugman</name></author><author><name sortKey="Bennett, Jp" uniqKey="Bennett J">JP Bennett</name></author><author><name sortKey="Wooten, Gf" uniqKey="Wooten G">GF Wooten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rossouw, Je" uniqKey="Rossouw J">JE Rossouw</name></author><author><name sortKey="Anderson, Gl" uniqKey="Anderson G">GL Anderson</name></author><author><name sortKey="Prentice, Rl" uniqKey="Prentice R">RL Prentice</name></author><author><name sortKey="Lacroix, Az" uniqKey="Lacroix A">AZ LaCroix</name></author><author><name sortKey="Kooperberg, C" uniqKey="Kooperberg C">C Kooperberg</name></author><author><name sortKey="Stefanick, Ml" uniqKey="Stefanick M">ML Stefanick</name></author><author><name sortKey="Jackson, Rd" uniqKey="Jackson R">RD Jackson</name></author><author><name sortKey="Beresford, Sa" uniqKey="Beresford S">SA Beresford</name></author><author><name sortKey="Howard, Bv" uniqKey="Howard B">BV Howard</name></author><author><name sortKey="Johnson, Kc" uniqKey="Johnson K">KC Johnson</name></author><author><name sortKey="Kotchen, Jm" uniqKey="Kotchen J">JM Kotchen</name></author><author><name sortKey="Ockene, J" uniqKey="Ockene J">J Ockene</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Esposito, E" uniqKey="Esposito E">E Esposito</name></author><author><name sortKey="Rotilio, D" uniqKey="Rotilio D">D Rotilio</name></author><author><name sortKey="Di Matteo, V" uniqKey="Di Matteo V">V Di Matteo</name></author><author><name sortKey="Di Giulio, C" uniqKey="Di Giulio C">C Di Giulio</name></author><author><name sortKey="Cacchio, M" uniqKey="Cacchio M">M Cacchio</name></author><author><name sortKey="Algeri, S" uniqKey="Algeri S">S Algeri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Di Matteo, V" uniqKey="Di Matteo V">V Di Matteo</name></author><author><name sortKey="Esposito, E" uniqKey="Esposito E">E Esposito</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Blanchet, J" uniqKey="Blanchet J">J Blanchet</name></author><author><name sortKey="Longpre, F" uniqKey="Longpre F">F Longpre</name></author><author><name sortKey="Bureau, G" uniqKey="Bureau G">G Bureau</name></author><author><name sortKey="Morissette, M" uniqKey="Morissette M">M Morissette</name></author><author><name sortKey="Dipaolo, T" uniqKey="Dipaolo T">T Dipaolo</name></author><author><name sortKey="Bronchti, G" uniqKey="Bronchti G">G Bronchti</name></author><author><name sortKey="Martinoli, Mg" uniqKey="Martinoli M">MG Martinoli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mehler Wex, C" uniqKey="Mehler Wex C">C Mehler-Wex</name></author><author><name sortKey="Riederer, P" uniqKey="Riederer P">P Riederer</name></author><author><name sortKey="Gerlach, M" uniqKey="Gerlach M">M Gerlach</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Salahpour, A" uniqKey="Salahpour A">A Salahpour</name></author><author><name sortKey="Ramsey, Aj" uniqKey="Ramsey A">AJ Ramsey</name></author><author><name sortKey="Medvedev, Io" uniqKey="Medvedev I">IO Medvedev</name></author><author><name sortKey="Kile, B" uniqKey="Kile B">B Kile</name></author><author><name sortKey="Sotnikova, Td" uniqKey="Sotnikova T">TD Sotnikova</name></author><author><name sortKey="Holmstrand, E" uniqKey="Holmstrand E">E Holmstrand</name></author><author><name sortKey="Ghisi, V" uniqKey="Ghisi V">V Ghisi</name></author><author><name sortKey="Nicholls, Pj" uniqKey="Nicholls P">PJ Nicholls</name></author><author><name sortKey="Wong, L" uniqKey="Wong L">L Wong</name></author><author><name sortKey="Murphy, K" uniqKey="Murphy K">K Murphy</name></author><author><name sortKey="Sesack, Sr" uniqKey="Sesack S">SR Sesack</name></author><author><name sortKey="Wightman, Rm" uniqKey="Wightman R">RM Wightman</name></author><author><name sortKey="Gainetdinov, Rr" uniqKey="Gainetdinov R">RR Gainetdinov</name></author><author><name sortKey="Caron, Mg" uniqKey="Caron M">MG Caron</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Itano, Y" uniqKey="Itano Y">Y Itano</name></author><author><name sortKey="Kitamura, Y" uniqKey="Kitamura Y">Y Kitamura</name></author><author><name sortKey="Nomura, Y" uniqKey="Nomura Y">Y Nomura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fall, Cp" uniqKey="Fall C">CP Fall</name></author><author><name sortKey="Bennett, Jp" uniqKey="Bennett J">JP Bennett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sirato Yasumoto, S" uniqKey="Sirato Yasumoto S">S Sirato-Yasumoto</name></author><author><name sortKey="Katsuta, M" uniqKey="Katsuta M">M Katsuta</name></author><author><name sortKey="Okuyama, Y" uniqKey="Okuyama Y">Y Okuyama</name></author><author><name sortKey="Takahashi, Y" uniqKey="Takahashi Y">Y Takahashi</name></author><author><name sortKey="Ide, T" uniqKey="Ide T">T Ide</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kushiro, M" uniqKey="Kushiro M">M Kushiro</name></author><author><name sortKey="Takahashi, Y" uniqKey="Takahashi Y">Y Takahashi</name></author><author><name sortKey="Ide, T" uniqKey="Ide T">T Ide</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ikeda, S" uniqKey="Ikeda S">S Ikeda</name></author><author><name sortKey="Abe, C" uniqKey="Abe C">C Abe</name></author><author><name sortKey="Uchida, T" uniqKey="Uchida T">T Uchida</name></author><author><name sortKey="Ichikawa, T" uniqKey="Ichikawa T">T Ichikawa</name></author><author><name sortKey="Horio, F" uniqKey="Horio F">F Horio</name></author><author><name sortKey="Yamashita, K" uniqKey="Yamashita K">K Yamashita</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="An, Lj" uniqKey="An L">LJ An</name></author><author><name sortKey="Guan, S" uniqKey="Guan S">S Guan</name></author><author><name sortKey="Shi, Gf" uniqKey="Shi G">GF Shi</name></author><author><name sortKey="Bao, Ym" uniqKey="Bao Y">YM Bao</name></author><author><name sortKey="Duan, Yl" uniqKey="Duan Y">YL Duan</name></author><author><name sortKey="Jiang, B" uniqKey="Jiang B">B Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hou, Rc" uniqKey="Hou R">RC Hou</name></author><author><name sortKey="Wu, Cc" uniqKey="Wu C">CC Wu</name></author><author><name sortKey="Yang, Ch" uniqKey="Yang C">CH Yang</name></author><author><name sortKey="Jeng, Kc" uniqKey="Jeng K">KC Jeng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jung, Tw" uniqKey="Jung T">TW Jung</name></author><author><name sortKey="Lee, Jy" uniqKey="Lee J">JY Lee</name></author><author><name sortKey="Shim, Ws" uniqKey="Shim W">WS Shim</name></author><author><name sortKey="Kang, Es" uniqKey="Kang E">ES Kang</name></author><author><name sortKey="Kim, Sk" uniqKey="Kim S">SK Kim</name></author><author><name sortKey="Ahn, Cw" uniqKey="Ahn C">CW Ahn</name></author><author><name sortKey="Lee, Hc" uniqKey="Lee H">HC Lee</name></author><author><name sortKey="Cha, Bs" uniqKey="Cha B">BS Cha</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gonzalez Polo, Ra" uniqKey="Gonzalez Polo R">RA Gonzalez-Polo</name></author><author><name sortKey="Soler, G" uniqKey="Soler G">G Soler</name></author><author><name sortKey="Rodriguezmartin, A" uniqKey="Rodriguezmartin A">A Rodriguezmartin</name></author><author><name sortKey="Moran, Jm" uniqKey="Moran J">JM Moran</name></author><author><name sortKey="Fuentes, Jm" uniqKey="Fuentes J">JM Fuentes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, J" uniqKey="Chen J">J Chen</name></author><author><name sortKey="Tang, Xq" uniqKey="Tang X">XQ Tang</name></author><author><name sortKey="Zhi, Jl" uniqKey="Zhi J">JL Zhi</name></author><author><name sortKey="Cui, Y" uniqKey="Cui Y">Y Cui</name></author><author><name sortKey="Yu, Hm" uniqKey="Yu H">HM Yu</name></author><author><name sortKey="Tang, Eh" uniqKey="Tang E">EH Tang</name></author><author><name sortKey="Sun, Sn" uniqKey="Sun S">SN Sun</name></author><author><name sortKey="Feng, Jq" uniqKey="Feng J">JQ Feng</name></author><author><name sortKey="Chen, Px" uniqKey="Chen P">PX Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bureau, G" uniqKey="Bureau G">G Bureau</name></author><author><name sortKey="Longpre, F" uniqKey="Longpre F">F Longpre</name></author><author><name sortKey="Martinoli, Mg" uniqKey="Martinoli M">MG Martinoli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bi, Xl" uniqKey="Bi X">XL Bi</name></author><author><name sortKey="Yang, Jy" uniqKey="Yang J">JY Yang</name></author><author><name sortKey="Dong, Yx" uniqKey="Dong Y">YX Dong</name></author><author><name sortKey="Wang, Jm" uniqKey="Wang J">JM Wang</name></author><author><name sortKey="Cui, Yh" uniqKey="Cui Y">YH Cui</name></author><author><name sortKey="Ikeshima, T" uniqKey="Ikeshima T">T Ikeshima</name></author><author><name sortKey="Zhao, Yq" uniqKey="Zhao Y">YQ Zhao</name></author><author><name sortKey="Wu, Cf" uniqKey="Wu C">CF Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, R" uniqKey="Li R">R Li</name></author><author><name sortKey="Huang, Yg" uniqKey="Huang Y">YG Huang</name></author><author><name sortKey="Fang, D" uniqKey="Fang D">D Fang</name></author><author><name sortKey="Le, Wd" uniqKey="Le W">WD Le</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Mj" uniqKey="Wang M">MJ Wang</name></author><author><name sortKey="Lin, Ww" uniqKey="Lin W">WW Lin</name></author><author><name sortKey="Chen, Hl" uniqKey="Chen H">HL Chen</name></author><author><name sortKey="Chang, Yh" uniqKey="Chang Y">YH Chang</name></author><author><name sortKey="Ou, Hc" uniqKey="Ou H">HC Ou</name></author><author><name sortKey="Kuo, Js" uniqKey="Kuo J">JS Kuo</name></author><author><name sortKey="Hong, Js" uniqKey="Hong J">JS Hong</name></author><author><name sortKey="Jeng, Kc" uniqKey="Jeng K">KC Jeng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hou, Rc" uniqKey="Hou R">RC Hou</name></author><author><name sortKey="Huang, Hm" uniqKey="Huang H">HM Huang</name></author><author><name sortKey="Tzen, Jt" uniqKey="Tzen J">JT Tzen</name></author><author><name sortKey="Jeng, Kc" uniqKey="Jeng K">KC Jeng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hou, Rc" uniqKey="Hou R">RC Hou</name></author><author><name sortKey="Chen, Hl" uniqKey="Chen H">HL Chen</name></author><author><name sortKey="Tzen, Jt" uniqKey="Tzen J">JT Tzen</name></author><author><name sortKey="Jeng, Kc" uniqKey="Jeng K">KC Jeng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gao, Jp" uniqKey="Gao J">JP Gao</name></author><author><name sortKey="Sun, S" uniqKey="Sun S">S Sun</name></author><author><name sortKey="Li, Ww" uniqKey="Li W">WW Li</name></author><author><name sortKey="Chen, Yp" uniqKey="Chen Y">YP Chen</name></author><author><name sortKey="Cai, Df" uniqKey="Cai D">DF Cai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gomez Santos, C" uniqKey="Gomez Santos C">C Gomez-Santos</name></author><author><name sortKey="Francisco, R" uniqKey="Francisco R">R Francisco</name></author><author><name sortKey="Gimenez Xavier, P" uniqKey="Gimenez Xavier P">P Gimenez-Xavier</name></author><author><name sortKey="Ambrosio, S" uniqKey="Ambrosio S">S Ambrosio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hunot, S" uniqKey="Hunot S">S Hunot</name></author><author><name sortKey="Dugas, N" uniqKey="Dugas N">N Dugas</name></author><author><name sortKey="Faucheux, B" uniqKey="Faucheux B">B Faucheux</name></author><author><name sortKey="Hartmann, A" uniqKey="Hartmann A">A Hartmann</name></author><author><name sortKey="Tardieu, M" uniqKey="Tardieu M">M Tardieu</name></author><author><name sortKey="Debre, P" uniqKey="Debre P">P Debre</name></author><author><name sortKey="Agid, Y" uniqKey="Agid Y">Y Agid</name></author><author><name sortKey="Dugas, B" uniqKey="Dugas B">B Dugas</name></author><author><name sortKey="Hirsch, Ec" uniqKey="Hirsch E">EC Hirsch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mogi, M" uniqKey="Mogi M">M Mogi</name></author><author><name sortKey="Harada, M" uniqKey="Harada M">M Harada</name></author><author><name sortKey="Narabayashi, H" uniqKey="Narabayashi H">H Narabayashi</name></author><author><name sortKey="Inagaki, H" uniqKey="Inagaki H">H Inagaki</name></author><author><name sortKey="Minami, M" uniqKey="Minami M">M Minami</name></author><author><name sortKey="Nagatsu, T" uniqKey="Nagatsu T">T Nagatsu</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Bournival, Julie" sort="Bournival, Julie" uniqKey="Bournival J" first="Julie" last="Bournival">Julie Bournival</name><name sortKey="Carange, Julie" sort="Carange, Julie" uniqKey="Carange J" first="Julie" last="Carange">Julie Carange</name><name sortKey="Lahaie Collins, Vicky" sort="Lahaie Collins, Vicky" uniqKey="Lahaie Collins V" first="Vicky" last="Lahaie-Collins">Vicky Lahaie-Collins</name><name sortKey="Martinoli, Maria Grazia" sort="Martinoli, Maria Grazia" uniqKey="Martinoli M" first="Maria-Grazia" last="Martinoli">Maria-Grazia Martinoli</name><name sortKey="Plouffe, Marilyn" sort="Plouffe, Marilyn" uniqKey="Plouffe M" first="Marilyn" last="Plouffe">Marilyn Plouffe</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002144 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002144 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:2715194
|texte= Sesamin modulates tyrosine hydroxylase, superoxide dismutase, catalase, inducible NO synthase and interleukin-6 expression in dopaminergic cells under MPP+-induced oxidative stress
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:19794909" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |